Griffonia simplicifolia is a West African shrub. Griffonia simplicifolia is the largest source of the compound 5-HTP. Its seeds contain up to 20% 5-HTP, by weight. Studies that have been done on Griffonia simplicifolia suggest that when supplemented as an herb, it may rival the effects of supplementing 5-HTP in isolation.Additional studies are needed to determine whether supplementing Griffonia simplicifolia is truly comparable to supplementing 5-HTP.
Griffonia Simplicifolia (with the alternate name of Bandeiraea Simplicifolia) is a shrubbery used in African folk medicine where the seeds are used for aphrodisia and antibiotic purposes as well as a remedy for diarrhea, vomiting and stomachache; the leaves are used for the treatment of wounds and the leaf juice for bladder and kidney ailments. More recently, the plant appears to be used in the treatment of anxiety and depression, insomnia, migraine and headache, as well as the regulation of appetite leading to weight reduction in obese patients; all of these effects are said to be due to the 5-HTP content of Griffonia Simplicifolia which many supplements are now standardized for traditional usage of the seeds from Griffonia Simplicifolia are mostly for neural purposes and are closely tied into 5-HTP's known actions. The leaves have been used for purposes currently unexplainable by 5-HTP (which are at low concentrations in the leaves) and likely related to other molecules